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This is Patricia. Creating her next story. Not thinking about her acromegaly

Meet PALSONIFY. A once-daily oral medication for acromegaly.

PALSONIFY is a prescription medicine used to treat adults with acromegaly for whom surgery was not effective or surgery is not an option.

PALSONIFY helps control IGF-1 levels and symptoms so you can be in the moment*

Ready to ask about PALSONIFY? Use this discussion guide to get the conversation going with your healthcare provider.

Discussion guide

PALSONIFY is a prescription medicine used to treat adults with acromegaly for whom surgery was not effective or surgery is not an option.

*PALSONIFY maintained or lowered IGF-1 and reduced the severity of common acromegaly symptoms in most patients in clinical studies.
IGF-1=insulin-like growth factor 1.

Patricia, writer,
living with acromegaly

Who is PALSONIFY for?

People who want 
to change medications

Ready for a change? PALSONIFY may help—even if injections weren’t right for you.

People who have discontinued medication

Previous medication didn’t work for you? PALSONIFY is different.

People new to treatment

Just diagnosed but not right for surgery? Or had surgery but still not fully controlled?

Powerful yet predictable, PALSONIFY is proven to:

Lower and maintain  IGF-1 levels*

Normalize IGF-1 in 2 to 4 weeks*

Reduce symptoms of acromegaly†

For more information about the clinical study results for PALSONIFY, download the PALSONIFY brochure.

Download the brochure

*In a 24-week study of 111 people with acromegaly who were new to medication or restarting after a break, 56% of those taking PALSONIFY reached normal IGF-1 levels compared with 5% taking placebo. The majority of people who achieved IGF-1 normalization did so within the first 2 to 4 weeks. In a 36-week study of 58 people switching from injections, 83% of those taking PALSONIFY maintained normal IGF-1 levels compared with 4% taking placebo.

†In both studies, people taking PALSONIFY experienced reduction in the severity of common acromegaly symptoms.
IGF-1=insulin-like growth factor 1.

PALSONIFY side effects

For people who switched from injections: Most side effects in a clinical study were mild to moderate, stomach related, and similar to those seen with other acromegaly treatments.* Here’s what some people experienced:
  • Diarrhea (23%)
  • Nausea (13%)
  • Loss of appetite (10%)
  • Fluttering or racing heartbeat (palpitations) (7%)
  • Stomach bug–like symptoms (gastroenteritis) (7%)
Stomach-related side effects, like diarrhea and nausea, resolved without stopping PALSONIFY.
For people new to or restarting treatment: The most common side effects in a clinical study were mild to moderate, mostly stomach related, and generally didn’t require stopping treatment.† Here’s what some people experienced:
  • Diarrhea (33%)
  • Stomach pain or discomfort (19%)
  • Nausea (9%)
  • Slow heart rate (sinus bradycardia) (7%)
  • High blood sugar (7%)
Stomach-related side effects, like diarrhea and nausea, generally resolved without stopping PALSONIFY.

*PALSONIFY was evaluated in two phase 3 clinical trials. Results are from study 2, which followed 58 people switching from injections.

†PALSONIFY was evaluated in two phase 3 clinical trials. Results are from study 1, which followed 111 people new to or restarting medication.

Patricia, writer,
living with acromegaly

Ask your healthcare team about PALSONIFY

Use this step-by-step discussion guide to start the conversation about an injection-free treatment for acromegaly.

Discussion guide

Ready for PALSONIFY?

CrinetiCARE® can help you get started

Crinetics logo white

CrinetiCARE provides personalized support to help you navigate your treatment journey with PALSONIFY. Whether you have questions about insurance coverage, need help finding a healthcare provider, or are seeking a nurse educator, CrinetiCARE is here to help.

Contact us

Phone 844-CRN-HELP (844-276-4357)
Fax 844-CRN-FAXX (844-276-3299)

Available Monday to Friday, 8 AM to 8 PM ET

Quick start supply*

The quick start supply helps ensure you can begin therapy without delay while the CrinetiCARE team works on securing insurance coverage.

Copay assistance program*

If you have commercial insurance and are not covered by any federal- or government-funded program, you may be eligible to pay as little as $0 for PALSONIFY.This program can help save up to a maximum of $25,000 per calendar year.

Healthcare provider locator

Looking for a specialist? CrinetiCARE can help you locate trusted healthcare providers and specialists in your area.

Nurse educators

Our experienced nurses are available to offer ongoing support and education throughout your PALSONIFY treatment journey, so you never feel like you are managing it alone.

Patient assistance program*

Uninsured or underinsured? CrinetiCARE may be able to help provide PALSONIFY at no cost to eligible patients.

*For more information about CrinetiCARE programs, please call 844-CRN-HELP (844-276-4357).

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What is PALSONIFY?

  • PALSONIFY is a prescription medicine used to treat adults with acromegaly for whom surgery was not effective or surgery is not an option
  • It is not known if PALSONIFY is safe and effective in children

IMPORTANT SAFETY INFORMATION

What should I tell my healthcare provider before taking PALSONIFY?

Before taking PALSONIFY, tell your healthcare provider about all your medical conditions, including if you:

  • have gallbladder problems
  • have blood sugar control problems (low blood sugar or high blood sugar)
  • have problems with low heart rate
  • are pregnant or plan to become pregnant. It is not known if PALSONIFY will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if PALSONIFY passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take PALSONIFY.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. PALSONIFY may affect the way other medicines work, and other medicines may affect how PALSONIFY works.

Especially tell your healthcare provider if you take any medicines that can slow the heart rate.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

What are the possible side effects of PALSONIFY?

PALSONIFY may cause serious side effects including:

  • Gallbladder problems: PALSONIFY may cause problems with the gallbladder. Tell your healthcare provider if you have sudden pain in the upper right area of your stomach (abdomen), sudden pain in your right shoulder or between your shoulder blades, yellowing of your skin or the whites of your eyes, or pale stools.
  • Blood sugar problems: PALSONIFY may change hormone levels, potentially causing either high blood sugar (hyperglycemia), including diabetes, or low blood sugar (hypoglycemia). Tell your healthcare provider if you have problems with high or low blood sugar. Your healthcare provider will check your blood sugar when you start taking PALSONIFY or when your dose is changed.
  • Heart rate problems: Tell your healthcare provider if your heart is not beating normally.
  • Thyroid problems: PALSONIFY may keep your thyroid from releasing thyroid hormones, leading to hypothyroidism. Your thyroid function may be checked periodically during your treatment with PALSONIFY.
  • Fatty stools: PALSONIFY may cause your body to have problems with absorbing dietary fats. Tell your healthcare provider if you have any new or worsening symptoms, including fatty stools, changes in the color of your stools, loose stools, stomach (abdominal) bloating, or weight loss.
  • Low vitamin B12 levels in your blood: Your healthcare provider may check your vitamin B12 levels during treatment with PALSONIFY.

The most common side effects of PALSONIFY include diarrhea, pain in your stomach (abdominal) area, nausea and vomiting, decreased appetite, slow heart rate (bradycardia), high blood sugar levels (hyperglycemia), and irregular heartbeat (palpitations).

These are not all the possible side effects of PALSONIFY. For more information, ask your healthcare provider or pharmacist.

You are encouraged to report negative side effects to Crinetics Pharmaceuticals at 1-833-CRN-INFO (1-833-276-4636) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see Full Prescribing Information, including Patient Information, and talk to your doctor.

What is PALSONIFY?

  • PALSONIFY is a prescription medicine used to treat adults with acromegaly for whom surgery was not effective or surgery is not an option
  • It is not known if PALSONIFY is safe and effective in children

IMPORTANT SAFETY INFORMATION

What should I tell my healthcare provider before taking PALSONIFY?

Before taking PALSONIFY, tell your healthcare provider about all your medical conditions, including if you:

  • have gallbladder problems
  • have blood sugar control problems (low blood sugar or high blood sugar)
  • have problems with low heart rate
  • are pregnant or plan to become pregnant. It is not known if PALSONIFY will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if PALSONIFY passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take PALSONIFY.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. PALSONIFY may affect the way other medicines work, and other medicines may affect how PALSONIFY works.

Especially tell your healthcare provider if you take any medicines that can slow the heart rate.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

What are the possible side effects of PALSONIFY?

PALSONIFY may cause serious side effects including:

  • Gallbladder problems: PALSONIFY may cause problems with the gallbladder. Tell your healthcare provider if you have sudden pain in the upper right area of your stomach (abdomen), sudden pain in your right shoulder or between your shoulder blades, yellowing of your skin or the whites of your eyes, or pale stools.
  • Blood sugar problems: PALSONIFY may change hormone levels, potentially causing either high blood sugar (hyperglycemia), including diabetes, or low blood sugar (hypoglycemia). Tell your healthcare provider if you have problems with high or low blood sugar. Your healthcare provider will check your blood sugar when you start taking PALSONIFY or when your dose is changed.
  • Heart rate problems: Tell your healthcare provider if your heart is not beating normally.
  • Thyroid problems: PALSONIFY may keep your thyroid from releasing thyroid hormones, leading to hypothyroidism. Your thyroid function may be checked periodically during your treatment with PALSONIFY.
  • Fatty stools: PALSONIFY may cause your body to have problems with absorbing dietary fats. Tell your healthcare provider if you have any new or worsening symptoms, including fatty stools, changes in the color of your stools, loose stools, stomach (abdominal) bloating, or weight loss.
  • Low vitamin B12 levels in your blood: Your healthcare provider may check your vitamin B12 levels during treatment with PALSONIFY.

The most common side effects of PALSONIFY include diarrhea, pain in your stomach (abdominal) area, nausea and vomiting, decreased appetite, slow heart rate (bradycardia), high blood sugar levels (hyperglycemia), and irregular heartbeat (palpitations).

These are not all the possible side effects of PALSONIFY. For more information, ask your healthcare provider or pharmacist.

You are encouraged to report negative side effects to Crinetics Pharmaceuticals at 1-833-CRN-INFO (1-833-276-4636) or FDA at
1-800-FDA-1088 or www.fda.gov/medwatch.

Please see Full Prescribing Information, including Patient Information, and talk to your doctor.

Get personalized resources to help you on your treatment journey

Sign up to receive customized tips, tools, and support for managing your acromegaly with PALSONIFY.

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